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참여연구진

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김선기 (Kim, Sun-Ki)

교수/중앙대학교

skkim18@cau.ac.kr

Tel. +82-31-670-3261

Fax. 031-675-31

연구활동분야

- 효모의 대사공학적 설계를 통한 식품 소재생산
- 분비 대사경로 설계를 통한 효소 대량생산
- 미생물/효소를 이용한 생리활성 물질 변환
- 식품 내 독성물질 검출 및 저감화

수행 연구과제

- 샤페로닌 발현 및 스퍼디민 농도 조절을 통한 효모의 발효저해제에 대한 다중 내성 증대 (책임연구, 한국연구재단, 2018.03-2019.02)
- 고효율 셀룰로오스 분해 효소를 생산하기 위한 대장균의 공장화 기술 (책임연구, 한국연구재단, 2019.03-2022.02)

대표적 연구실적

- Elimination of biosynthetic pathways for L-valine and L-isoleucine in mitochondria enhances isobutanol production in engineered Saccharomyces cerevisiae. (2018) Bioresource Technology
- Engineering a spermidine biosynthetic pathway in Clostridium thermocellum results in increased resistance to furans and increased ethanol production. (2018) Metabolic Engineering
- Expression of a cellobiose phosphorylase from Thermotoga maritima in Caldicellulosiruptor bescii improves the phosphorolytic pathway and results in a dramatic increase in cellulolytic activity. (2018) Applied and Environmental Microbiology
- Heterologous expression of a β‑D‑glucosidase in Caldicellulosiruptor bescii has a surprisingly modest effect on the activity of the exoproteome and growth on crystalline cellulose. (2017) Journal of Industrial Microbiology and Biotechnology
- In vivo synergistic activity of a CAZyme cassette from Acidothermus cellulolyticus significantly improves the cellulolytic activity of the C. bescii exoproteome. (2017) Biotechnology and Bioengineering
- Metabolic engineering of Saccharomyces cerevisiae for production of spermidine under optimal culture conditions. (2017) Enzyme and Microbial Technology
- Engineering the N-terminal end of CelA results in improved performance and growth of Caldicellulosiruptor bescii on crystalline cellulose. (2017) Biotechnology and Bioengineering